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KMID : 0370219980420020181
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Yakhak Hoeji
1998 Volume.42 No. 2 p.181 ~ p.186
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Pharmacokinetics of Cyclosporine in Rabbits with Carbon Tetrachloride and Bile Duct Ligation-Induced Hepatic Disorder
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최준식/Choi JS
최병철/범진필/Choi BC/Burm JP
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Abstract
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This study was attempted to investigate the pharmacokinetics of cyclosporine (10mg/kg, oral) in rabbits with CC14 and bile duct ligation-induced hepatic disorder. The area under the curve (AUC) of blood cyclosporine concentration versus time was significantly increased (p4-induced hepatic disorder. Elimination rate constant (Kel) was significantly decreased (p<0.05, p<0.01) in rabbits with CC14 and bile duct ligation-induced hepatic disorder. Volume of distribution (Vdss) and total body clearance (CLtot) were significantly decreased (p<0.01) in rabbits with CC14-induced hepatic disorder. But Vdss was significantly increased (p4-induced hepatic disorder were 874ng/ml and 2.71 hr, respectively. Cmax and Tmax values in rabbits with bile duct ligation were 105ng/ml and 2.834 hr, respectively. From results of this experiment. It is desirable to do therapeutic drug monitoring of cyclosporine for effective treatment when the cyclosporine is administered to patients with liver disorder m clinical practice.
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